Paclitaxel Cas 33069-62-4 [email protected]

Paclitaxel [email protected] Molecular Formula: C47H51O14 Molecular Weight: 853.9182 Cas Number: 33069-62-4 Appearance: white powder Mesh: 80 mesh Active ingredient content: 97-99% HPLC Heavy Metal: <2PPM Loss on drying: <1% Ash: 0.2% Melting point: 213-215 ° C Specific rotation: -49 ~ -55 Function and use: Department of paclitaxel from the bark of the natural plant extract of Taxus diterpenoid alkaloid monomer compounds found in recent years, new mechanisms of cytotoxic anticancer drugs, is the world's The most effective new anti-microtubule drug, its promotion of tubulin polymerization by inhibiting the depolymerization of tubulin to maintain stability, and inhibition of cell mitosis. In vitro experiments show that taxol has significant radiosensitization, May be to stay on the radiation-sensitive cells G2 and M phase.Unique is that cancer does not affect the synthesisof DNA and RNA, or damage DNA molecules, which selectively promotes the rapid aggregation of tubulin into micro- Tube, combined to inhibit microtubule depolymerization of microtubules, thus affecting the spinning cone, inhibit cancer cell mitosis; or the payment of microtubule polymerization, inhibition of microtubule depolymerization and inhibition of cell division. Eggs on the clinical Ovarian cancer, breast cancer, non-small cell lung cancer, head and neck cancer such as a significant effect.